Forskningsprojekt och publikationer

Pågående forskningsprojekt och vetenskapliga publikationer som helt eller delvis är baserade på data från InfCareHIV finns listade här.

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Aktuella forskningsprojekt

Dessa forskningsprojekt baseras helt eller delvis på InfCareHIV.

Non-Hodkin lymphoma in people living with HIV; epidemiology, viral coinfection and survival

Kontakt: christina.carlander@ki.se

Behandlingseffekt och läkemedelsval hos kvinnor som lever med hiv i Sverige

Kontakt: maria.lindh@vgregion.se, Södra Älvsborgs sjukhus

NK-celler för indirect shock-and-kill-strategi vid behandling av HIV-1

Kontakt: anders.sonnerborg@ki.se, robert.van.domselaar.1@ki.se

Behandling av anal precancer

Kontakt: peter.thelin-schmidt@regionstockholm.se

HIV among people who inject drugs in Stockholm

Kontakt: martin.kaberg@ki.se

Time preferences and medical adherence

Kontakt: lisa.norrgren@infect.gu.se

Does fever after travel to tropical and subtropical areas merit HIV screening?

Kontakt: klara.sonden@ki.se

Development of bioinformatics for assessment of undiagnosed population and transmissionscluster in real-time

Kontakt: anders.sonnerborg@ki.se

The elite controller cohort

Kontakt: anders.sonnerborg@ki.se

Identification of biomarkers for personalized medicine in HIV care

Kontakt: piotr.nowak@ki.se, anders.sonnerborg@ki.se

Covid-19-related stigma among hiv infected people in Sweden

Kontakt: veronica.svedhem-johansson@regionstockholm

Publikationer

Akusjärvi SS, Ambikan AT, Krishnan S, Gupta S, Sperk M, Végvári Á, Mikaeloff F, Healy K, Vesterbacka J, Nowak P, Sönnerborg A, Neogi U.iScience. Integrative proteo-transcriptomic and immunophenotyping signatures of HIV-1 elite control phenotype: A cross-talk between glycolysis and HIF signaling.2021 Dec 10;25(1):103607. https://pubmed.ncbi.nlm.nih.gov/35005552/

Anesten B, Zetterberg H, Nilsson S, Brew BJ, Fuchs D, Price RW, Gisslén M, Yilmaz A. Effect of antiretroviral treatment on blood-brain barrier integrity in HIV-1 infection.BMC Neurol. 2021 Dec 22;21(1):494. doi: 10.1186/s12883-021-02527-8. PMID: 34937542 https://pubmed.ncbi.nlm.nih.gov/34937542/

Andersson E, Ambikan A, Brännström J, Aralaguppe S, Yilmaz A, Albert J, Neogi U, Sönnerborg A. High-throughput sequencing reveals a high rate of pre-treatment HIV-1 drug resistance in Sweden. AIDS. 2021 Feb 2;35(2):227-234. https://pubmed.ncbi.nlm.nih.gov/33394670/

Atkinson A, Zwahlen M, Barger D, d'Arminio Monforte A, De Wit S, Ghosn J, Girardi E, Svedhem V, Morlat P, Mussini C, Noguera-Julian A, Stephan C, Touloumi G, Kirk O, Mocroft A, Reiss P, Miro JM, Carpenter JR, Furrer H; Opportunistic Infections Project Working Group of the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord. Withholding Primary Pneumocystis Pneumonia Prophylaxis in Virologically Suppressed Patients With Human Immunodeficiency Virus: An Emulation of a Pragmatic Trial in COHERE. Clin Infect Dis. 2021 Jul 15;73(2):195-202. doi: 10.1093/cid/ciaa615.PMID: 32448894 https://pubmed.ncbi.nlm.nih.gov/32448894/

Bai X, Narayanan A, Nowak P, Ray S, Neogi U, Sönnerborg A. Whole genome metagenomic analysis of the gut microbiome in HIV-1 infected individuals on antiretroviral therapy. Front Microbiol. 2021 Jun 25;12:667718 https://pubmed.ncbi.nlm.nih.gov/34248876/

Bansi-Matharu L, Phillips A, Oprea C, Grabmeier-Pfistershammer K, Günthard HF, De Wit S, Guaraldi G, Vehreschild JJ, Wit F, Law M, Wasmuth JC, Chkhartishvili N, d'Arminio Monforte A, Fontas E, Vesterbacka J, Miro JM, Castagna A, Stephan C, Llibre JM, Neesgaard B, Greenberg L, Smith C, Kirk O, Duvivier C, Dragovic G, Lundgren J, Dedes N, Knudsen A, Gallant J, Vannappagari V, Peters L, Elbirt D, Sarcletti M, Braun DL, Necsoi C, Mussini C, Muccini C, Bolokadze N, Hoy J, Mocroft A, Ryom L. Contemporary antiretrovirals and body-mass index: a prospective study of the RESPOND cohort consortium. Lancet HIV. 2021 Nov;8(11):e711-e722. doi: 10.1016/S2352-3018(21)00163-6. Epub 2021 Sep 20. PMID: 34555326 https://pubmed.ncbi.nlm.nih.gov/34555326/

Bergman P, Blennow O, Hansson L, Mielke S, Nowak P, Chen P, Söderdahl G, Österborg A, Smith CIE, Wullimann D, Vesterbacka J, Lindgren G, Blixt L, Friman G, Wahren-Borgström E, Nordlander A, Gomez AC, Akber M, Valentini D, Norlin AC, Thalme A, Bogdanovic G, Muschiol S, Nilsson P, Hober S, Loré K, Chen MS, Buggert M, Ljunggren HG, Ljungman P, Aleman S; COVAXID-collaborator group (shown separately). Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial. EBioMedicine. 2021 Dec;74:103705. https://pubmed.ncbi.nlm.nih.gov/34861491/

Borghetti A, Ciccullo A, Lombardi F, Baldin G, Belmonti S, Prosperi M, Incardona F, Heger E, Borghi V, Sönnerborg A, Zazzi M, De Luca A, Di Giambenedetto S. Transmitted drug resistance to NRTIs and risk of virological failure in naïve patients treated with integrase inhibitors. HIV Med. 2021 Jan;22(1):22-27. https://pubmed.ncbi.nlm.nih.gov/32964671/

Caby F, Guiguet M, Weiss L, Winston A, Miro JM, Konopnicki D, Le Moing V, Bonnet F, Reiss P, Mussini C, Poizot-Martin I, Taylor N, Skoutelis A, Meyer L, Goujard C, Bartmeyer B, Boesecke C, Antinori A, Quiros-Roldan E, Wittkop L, Frederiksen C, Castagna A, Thurnheer MC, Svedhem V, Jose S, Costagliola D, Mary-Krause M, Grabar S; (CD4/CD8 ratio and cancer risk) project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord. CD4/CD8 Ratio and the Risk of Kaposi Sarcoma or Non-Hodgkin Lymphoma in the Context of Efficiently Treated Human Immunodeficiency Virus (HIV) Infection: A Collaborative Analysis of 20 European Cohort Studies. Clin Infect Dis. 2021 Jul 1;73(1):50-59. doi:10.1093/cid/ciaa1137.PMID: 34370842 https://pubmed.ncbi.nlm.nih.gov/34370842/

Carlander C, Lagheden C, Eklund C, Nordqvist Kleppe S, Dzabic M, Wagner P, Sparén P, Dillner J. Nonvaccine human papillomavirus genotype common in women with HIV failing cervical precancer treatment. AIDS 2021 Nov 15;35(14)2367-2374 https://pubmed.ncbi.nlm.nih.gov/34723851/

Carlander C, Wagner P, Yilmaz A, Sparén P, Svedhem V. Employment by HIV status, mode of HIV transmission and migrant status: a nation-wide population-based study with twenty years of follow-up. AIDS 2021 Jan 1;35(1):115-123. https://pubmed.ncbi.nlm.nih.gov/33048876/

Carlsson-Lalloo E, Rusner M, Berg M, Svedhem V, Mellgren Å. People living with HIV in Sweden report high levels of sexual satisfaction in a registry-based cohort study. AIDS Care. 2021 Apr 1:1-9. https://pubmed.ncbi.nlm.nih.gov/33793361/

Olof Elvstam, Gaetano Marrone, Patrik Medstrand, Carl Johan Treutiger, Anders Sönnerborg, Magnus Gisslén, Per Björkman. All-Cause Mortality and Serious Non-AIDS Events in Adults With Low-level Human Immunodeficiency Virus Viremia During Combination Antiretroviral Therapy: Results From a Swedish Nationwide Observational Study. Clinical Infectious Diseases, Volume 72, Issue 12, 15 June 2021, Pages 2079–2086 https://pubmed.ncbi.nlm.nih.gov/32271361/

Olof Elvstam, Gaetano Marrone, Patrik Medstrand, Carl Johan Treutiger, Veronica Svedhem, Magnus Gisslén, Per Björkman. Associations Between Plasma Human Immunodeficiency Virus (HIV) Ribonucleic Acid Levels and Incidence of Invasive Cancer in People With HIV After Initiation of Combination Antiretroviral Therapy. Open Forum Infectious Diseases, Volume 8, Issue 6, June 2021 https://pubmed.ncbi.nlm.nih.gov/34189159/

Gisslen M, Keating SM, Spudich S, Arechiga V, Stephenson S, Zetterberg H, Di Germanio C, Blennow K, Fuchs D, Hagberg L, Norris PJ, Peterson J, Shacklett BL, Yiannoutsos CT, Price RW. Compartmentalization of cerebrospinal fluid inflammation across the spectrum of untreated HIV-1 infection, central nervous system injury and viral suppression. PLoS One. 2021 May 13;16(5):e0250987. doi: 10.1371/journal.pone.0250987. https://pubmed.ncbi.nlm.nih.gov/33983973/

Jiang W, Luo Z, Stephenson S, Li H, Di Germanio C, Norris PJ, Fuchs D, Zetterberg H, Gisslen M, Price RW. Cerebrospinal Fluid and Plasma Lipopolysaccharide Levels in Human Immunodeficiency Virus Type 1 Infection and Associations With Inflammation, Blood-Brain Barrier Permeability, and Neuronal Injury.J Infect Dis. 2021 May 20;223(9):1612-1620. doi: 10.1093/infdis/jiaa765. PMID: 33320240 https://pubmed.ncbi.nlm.nih.gov/33320240/

Kieri O, Marrone G, Sönnerborg A, Nowak P. Incidence, treatment and outcome of HIV-associated hematologic malignancies in people living with HIV in Sweden. AIDS Research and Human Retroviruses 2021 https://pubmed.ncbi.nlm.nih.gov/34652958/

Malmström S, Wagner P, Yilmaz A, Svedhem V, Carlander C. Failure to restore CD4+ cell count associated with infection-related and noninfection-related cancer. AIDS 2021 Online ahead of print Oct 27. https://pubmed.ncbi.nlm.nih.gov/34711738/

Pelchen-Matthews A, Borges ÁH, Reekie J, Rasmussen LD, Wiese L, Weber J, Pradier C, Degen O, Paredes R, Tau L, Flamholc L, Gottfredsson M, Kowalska J, Jablonowska E, Mozer-Lisewska I, Radoi R, Vasylyev M, Kuznetsova A, Begovac J, Svedhem V, Clark A, Cozzi-Lepri A; EuroSIDA study. Prevalence and Outcomes for Heavily Treatment-Experienced Individuals Living With Human Immunodeficiency Virus in a European Cohort. J Acquir Immune Defic Syndr. 2021 Jun 1;87(2):806-817. https://pubmed.ncbi.nlm.nih.gov/33587506/

Ray S, Narayanan A, Giske CG, Neogi U, Sönnerborg A, Nowak P. Altered Gut Microbiome under Antiretroviral Therapy: Impact of Efavirenz and Zidovudine.ACS Infect Dis. 2021 May 14;7(5):1104-1115. doi: 10.1021/acsinfecdis.0c00536. https://pubmed.ncbi.nlm.nih.gov/33346662/

The RESPOND Study Group, including Sönnerborg A. Incidence of dyslipidemia in people with HIV who are treated with integrase inhibitors versus other antiretroviral agents. AIDS 2021 May 1;35(6):869-992 https://pubmed.ncbi.nlm.nih.gov/33443370/

Reinius M, Zeluf Andersson G, Svedhem V, Wettergren L, Wiklander M, Eriksson LE. Towards a new understanding of HIV-related stigma in the era of efficient treatment- A qualitative reconceptualization of existing theory. J Adv Nurs. 2021 May;77(5):2472-2480. https://pubmed.ncbi.nlm.nih.gov/33599309/

Rossetti B; Fabbiani M; Domenico DC; Incardona, F; Abecasis, A; Gomes, P; Geretti, A; Seguin-Devaux, C; Garcia, F; Kaiser, R; Modica, S; Shallvari, A; Sonnerborg, A; Zazzi, M. Effectiveness of integrase strand transfer inhibitor-based regimens in HIV-infected treatment-experienced individuals: results from a European multicohort study. J Antimicrob Chemother. 2021 Aug 12;76(9)2394-2399 https://pubmed.ncbi.nlm.nih.gov/34212176/

Saccon E, Mikaeloff F, Ivern PF, Végvári A, Neogi U, Sönnerborg A, van Domselaar R. Cytotoxic lymphocyte protease granzyme M is differentially expressed in Elite Controllers and targets HIV-1 Gag protein. Front Immunol. 2021 Apr 19;12:669347. https://pubmed.ncbi.nlm.nih.gov/33953729/

Sperk M, Ambikan A, Ray S, Singh K, Mikaeloff F, Diez R, Narayanan A, Vesterbacka J, Nowak P, Sönnerborg A, Neogi U. Fecal Metabolome Signature in HIV-1 Elite Control Phenotype: Enrichment of Dipeptides Act as HIV-1 Antagonist but Prevotella Agonist. J Virol. 2021 Aug 25;95(18) https://pubmed.ncbi.nlm.nih.gov/34232744/

Sperk M, Mikaeloff F, Svensson-Akusjärvi S, Krishnan S, Ponnan SM, Ambikan AT, Nowak P, Sönnerborg A, Neogi U.iScience. Distinct lipid profile, low-level inflammation, and increased antioxidant defense signature in HIV-1 elite control status.2021 Jan 28;24(2):102111. doi: 10.1016/j.isci.2021.102111 https://pubmed.ncbi.nlm.nih.gov/33659876/

Tyrberg E, Edén A, Eriksen J, Nilsson S, Treutiger CJ, Thalme A, Mellgren Å, Gisslén M, Andersson LM. Higher plasma drug levels in elderly people living with HIV treated with darunavir. PLoS One. 2021 Feb 4;16(2):e0246171. doi: 10.1371/journal.pone.0246171. https://pubmed.ncbi.nlm.nih.gov/33539440/

Ulfhammer G, Edén A, Antinori A, Brew BJ, Calcagno A, Cinque P, De Zan V, Hagberg L, Lin A, Nilsson S, Oprea C, Pinnetti C, Spudich S, Trunfio M, Winston A, Price RW, Gisslén M. Cerebrospinal Fluid viral load across the spectrum of untreated HIV-1 infection: a cross-sectional multi-center study. Clin Infect Dis. 2021 Nov 8:ciab943. doi: 10.1093/cid/ciab943. Online ahead of print. PMID: 34747481 https://pubmed.ncbi.nlm.nih.gov/34747481/

Forskningsprojekt och publikationer

Aktuella forskningsprojekt

Studier av hivreservoarer

Låggradig viremi och komorbiditet

HIV och CNS

TIME-studien

Hivbehandling under graviditet

Långtidsuppföljning av barn infekterade i samband med förlossning

PROM & PREM

Risk for severe Covid-19 in people with HIV